Placebo Washout in Trials of Antipsychotic Drugs
نویسندگان
چکیده
منابع مشابه
Dropout rates in placebo-controlled and active-control clinical trials of antipsychotic drugs: a meta-analysis.
CONTEXT Dropout rates in randomized clinical trials of antipsychotic drugs have consistently been reported to be high, and the use of a placebo-controlled design is hypothesized to be one of the reasons for this. OBJECTIVE To investigate this hypothesis in a meta-analysis of available data from pertinent clinical trials. DATA SOURCES Comprehensive search of PubMed- and MEDLINE-listed journa...
متن کاملAntipsychotic Drugs
The term psychosis refers to a variety of mental disorders characterized by one or more of the following symptoms: diminished and distorted capacity to process information and draw logical conclusions, hallucinations, delusions, incoherence or marked loosening of associations, catatonic or disorganized behavior, and aggression or violence. Antipsychotic drugs lessen these symptoms regardless of...
متن کاملPlacebo-controlled trials of new drugs: ethical considerations.
Much controversy exists regarding the ethics of placebo-controlled trials in which an experimental therapy will compete with an already established treatment (or treatments). In such cases, argue critics, patients in the control arm of the study should receive an accepted therapy rather than a placebo. By using an active and effective drug, the control patients would not be placed at risk for d...
متن کاملAtypical antipsychotic augmentation in major depressive disorder: a meta-analysis of placebo-controlled randomized trials.
OBJECTIVE The authors sought to determine by meta-analysis the efficacy and tolerability of adjunctive atypical antipsychotic agents in major depressive disorder. METHOD Searches were conducted of MEDLINE/PubMed (1966 to January 2009), the Cochrane database, abstracts of major psychiatric meetings since 2000, and online trial registries. Manufacturers of atypical antipsychotic agents without ...
متن کاملConsistency of atypical antipsychotic superiority to placebo in recent clinical trials.
BACKGROUND The use of control placebos in clinical trials of new antipsychotic medications is increasingly under examination. The active controlled equivalence study could offer a potential alternative design. First, however, it must be clear that any proposed standard control agent has been consistently superior to placebo in previous studies. METHODS Through a Freedom of Information Act req...
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ژورنال
عنوان ژورنال: Schizophrenia Bulletin
سال: 1996
ISSN: 0586-7614,1745-1701
DOI: 10.1093/schbul/22.4.567